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  Functional remodeling of the contractile smooth muscle cell cortex, a provocative concept, supported by direct visualization of cortical remodeling 

  Suphamungmee, Worawit; Lehman, William; Morgan, Kathleen G. (MDPI AG, 2022-04-26)

  Considerable controversy has surrounded the functional anatomy of the cytoskeleton of the contractile vascular smooth muscle cell. Recent studies have suggested a dynamic nature of the cortical cytoskeleton of these cells, ...
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  Probing the neural circuitry targets of neurotoxicants in vivo through high density silicon probe brain implants 

  Ratner, Marcia; Farb, David (Frontiers, 2022-04-22)

  Adverse effects of drugs on the human nervous system are rarely possible to anticipate based on preclinical neurotoxicity data, thus propagating the centuries long single most important obstacle to drug discovery and ...
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  Neuroimaging markers for studying Gulf-War illness: single-subject level analytical method based on machine learning 

  Guan, Yi; Cheng, Chia-Hsin; Chen, Weifan; Zhang, Yingqi; Koo, Sophia; Krengel, Maxine; Janulewicz, Patricia; Toomey, Rosemary; Yang, Ehwa; Bhadelia, Rafeeque; Steele, Lea; Kim, Jae-Hun; Sullivan, Kimberly; Koo, Bang-Bon (2020-11-20)

  Gulf War illness (GWI) refers to the multitude of chronic health symptoms, spanning from fatigue, musculoskeletal pain, and neurological complaints to respiratory, gastrointestinal, and dermatologic symptoms experienced ...
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  Klotho pathways, myelination disorders, neurodegenerative diseases, and epigenetic drugs 

  Moos, Walter H.; Faller, Douglas V.; Glavas, Ioannis P.; Harpp, David N.; Kanara, Iphigenia; Mavrakis, Anastasios N.; Pernokas, Julie; Pernokas, Mark; Pinkert, Carl A.; Powers, Whitney R.; Sampani, Konstantina; Steliou, Kosta; Vavvas, Demetrios G.; Zamboni, Robert J.; Kodukula, Krishna; Chen, Xiaohong (Mary Ann Liebert, Inc., 2020)

  In this review we outline a rationale for identifying neuroprotectants aimed at inducing endogenous Klotho activity and expression, which is epigenetic action, by definition. Such an approach should promote remyelination ...
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  Epigenetic treatment of dermatologic disorders 

  Moos, Walter H.; Faller, Douglas V.; Glavas, Ioannis P.; Harpp, David N.; Kanara, Iphigenia; Pinkert, Carl A.; Powers, Whitney R.; Sampani, Konstantina; Steliou, Kosta; Vavvas, Demetrios G.; Kodukula, Krishna; Zamboni, Robert J. (Wiley, 2019-09)

  Healthy skin protects us against a multitude of insults but injured or maladapted skin can lead to infection, inflammation or worse. Fortunately, naturally occurring bioactive products, many commonly found in olive oil and ...
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  Robust visualization and discrimination of nanoparticles by interferometric imaging 

  Trueb, Jacob; Avci, Oguzhan; Sevenler, Derin; Connor, John H.; Ünlü, M. Selim (2017-03)

  Single-molecule and single-nanoparticle biosensors are a growing frontier in diagnostics. Digital biosensors are those which enumerate all specifically immobilized biomolecules or biological nanoparticles, and thereby ...
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  Enhanced light microscopy visualization of virus particles from Zika virus to filamentous ebolaviruses 

  Daaboul, George G.; Freedman, David S.; Scherr, Steven M.; Carter, Erik; Rosca, Alexandru; Bernstein, David; Mire, Chad E.; Agans, Krystle N.; Hoenen, Thomas; Geisbert, Thomas W.; Unlu, M. Selim; Connor, John H. (PUBLIC LIBRARY SCIENCE, 2017-06-26)

  Light microscopy is a powerful tool in the detection and analysis of parasites, fungi, and prokaryotes, but has been challenging to use for the detection of individual virus particles. Unlabeled virus particles are too ...
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  A new approach to treating neurodegenerative otologic disorders 

  Moos, Walter H.; Faller, Douglas V.; Glavas, Ioannis P.; Harpp, David N.; Irwin, Michael H.; Kanara, Iphigenia; Pinkert, Carl A.; Powers, Whitney R.; Steliou, Kosta; Vavvas, Demetrios G.; Kodukula, Krishna (2018)

  Hearing loss, the most common neurological disorder and the fourth leading cause of years lived with disability, can have profound effects on quality of life. The impact of this "invisible disability," with significant ...
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  Neuroprotective effects of carnitinoid compounds in rodent cellular and in vivo models of mitochondrial complex I dysfunction 

  Steliou, Kosta (Mesford Publisher Inc, 2019-03-13)

  Rotenone-mediated mitochondrial complex I inhibition was used to model Parkinson’s disease-like syndrome in Lewis rats. Tyrosine hydroxylase immunolabeling demonstrated a decrease in the number of dopaminergic neurons as ...
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  Epigenetic treatment of neurodegenerative ophthalmic disorders: an eye toward the future. 

  Moos, Walter H.; Faller, Douglas V.; Glavas, Ioannis P.; Harpp, David N.; Irwin, Michael H.; Kanara, Iphigenia; Pinkert, Carl A.; Powers, Whitney R.; Steliou, Kosta; Vavvas, Demetrios G.; Kodukula, Krishna (2017)

  Eye disease is one of the primary medical conditions that requires attention and therapeutic intervention in ageing populations worldwide. Further, the global burden of diabetes and obesity, along with heart disease, all ...

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