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  Probing the neural circuitry targets of neurotoxicants in vivo through high density silicon probe brain implants 

  Ratner, Marcia; Farb, David (Frontiers, 2022-04-22)

  Adverse effects of drugs on the human nervous system are rarely possible to anticipate based on preclinical neurotoxicity data, thus propagating the centuries long single most important obstacle to drug discovery and ...
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  UFD1 contributes to MYC-mediated leukemia aggressiveness through suppression of the proapoptotic unfolded protein response 

  Huiting, L.N.; Samaha, Y.; Zhang, Guanglan; Roderick, J.E.; Li, B.; Anderson, N.M.; Wang, Y.W.; Wang, L.; Laroche, F.J.F.; Choi, J.W.; Liu, C.T.; Kelliher, M.A.; Feng, Hui (Nature Publishing Group, 2018-04-25)

  Despite the pivotal role of MYC in tumorigenesis, the mechanisms by which it promotes cancer aggressiveness remain incompletely understood. Here, we show that MYC transcriptionally upregulates the ubiquitin fusion degradation ...
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  Quantitative Observations of Fever and Its Treatment before the Advent of Short Clinical Thermometers. 

  Estes, J. W. (1991-04)
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  Cell Density Plays a Critical Role in Ex Vivo Expansion of T Cells for Adoptive Immunotherapy 

  Ma, Qiangzhong; Wang, Yawen; Lo, Agnes Shuk-Yee; Gomes, Erica M.; Junghans, Richard P. (Hindawi Publishing Corporation, 2010-6-30)

  The successful ex vivo expansion of a large numbers of T cells is a prerequisite for adoptive immunotherapy. In this study, we found that cell density had important effects on the process of expansion of T cells in vitro. ...
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  Pharmacological Properties of DOV 315,090, an Ocinaplon Metabolite 

  Berezhnoy, Dmytro; Gravielle, Maria C.; Downing, Scott; Kostakis, Emmanuel; Basile, Anthony S.; Skolnick, Phil; Gibbs, Terrell T.; Farb, David H. (BioMed Central, 2008-6-13)

  BACKGROUND. Compounds targeting the benzodiazepine binding site of the GABAA-R are widely prescribed for the treatment of anxiety disorders, epilepsy, and insomnia as well as for pre-anesthetic sedation and muscle relaxation. ...
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  Signaling Pathways Required for Macrophage Scavenger Receptor-Mediated Phagocytosis: Analysis by Scanning Cytometry 

  Sulahian, Timothy H; Imrich, Amy; DeLoid, Glen; Winkler, Aaron R; Kobzik, Lester (BioMed Central, 2008-8-7)

  BACKGROUND. Scavenger receptors are important components of the innate immune system in the lung, allowing alveolar macrophages to bind and phagocytose numerous unopsonized targets. Mice with genetic deletions of scavenger ...
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  Tar DNA binding Protein-43 (TDP-43) associates with stress granules: analysis of cultured cells and pathological brain tissue 

  Liu-Yesucevitz, Liqun; Bilgutay, Aylin; Zhang, Yong-Jie; Vanderwyde, Tara; Citro, Allison; Mehta, Tapan; Zaarur, Nava; McKee, Ann; Bowser, Robert; Sherman, Michael; Petrucelli, Leonard; Wolozin, Benjamin (Public Library of Science, 2010-10-11)

  Tar DNA Binding Protein-43 (TDP-43) is a principle component of inclusions in many cases of frontotemporal lobar degeneration (FTLD-U) and amyotrophic lateral sclerosis (ALS). TDP-43 resides predominantly in the nucleus, ...
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  Control of Activating Transcription Factor 4 (ATF4) Persistence by Multisite Phosphorylation Impacts Cell Cycle Progression and Neurogenesis* 

  Frank, Christopher L.; Ge, Xuecai; Xie, Zhigang; Zhou, Ying; Tsai, Li-Huei (American Society for Biochemistry and Molecular Biology, 2010-8-19)

  Organogenesis is a highly integrated process with a fundamental requirement for precise cell cycle control. Mechanistically, the cell cycle is composed of transitions and thresholds that are controlled by coordinated ...
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  Oxysterol-Binding Protein-1 (OSBP1) Modulates Processing and Trafficking of the Amyloid Precursor Protein 

  Zerbinatti, Celina V.; Cordy, Joanna M.; Chen, Ci-Di; Guillily, Maria; Suon, Sokreine; Ray, William J.; Seabrook, Guy R.; Abraham, Carmela R.; Wolozin, Benjamin (BioMed Central, 2008-3-18)

  BACKGROUND Evidence from biochemical, epidemiological and genetic findings indicates that cholesterol levels are linked to amyloid-β (Aβ) production and Alzheimer's disease (AD). Oxysterols, which are cholesterol-derived ...
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  Positional Clustering Improves Computational Binding Site Detection and Identifies Novel Cis-Regulatory Sites in Mammalian GABAA Receptor Subunit Genes 

  Reddy, Timothy E.; Shakhnovich, Boris E.; Roberts, Daniel S.; Russek, Shelley J.; DeLisi, Charles (Oxford University Press, 2007-01-03)

  Understanding transcription factor (TF) mediated control of gene expression remains a major challenge at the interface of computational and experimental biology. Computational techniques predicting TF-binding site specificity ...

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