Department of Anatomy and Neurobiology
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The mission of the Department of Anatomy & Neurobiology is to advance our knowledge of clinical, systems, and cellular neuroscience, focusing on the structure, organization, and function of cerebral systems, and to produce the next generation of educators for medical and graduate schools for the 21st century.
With roots tracing back to 1886, the Department is nationally recognized for its strong research programs in neuroscience and its innovative discoveries over the past 50 years. These discoveries include: The identification of fine structural components of neurons (spines, axons, myelin); seminal structural descriptions of the neuroanatomical features of autism and dyslexia; mapping of the organization and connectivity of neocortical circuits; discovery of the preservation of cortical neurons but damage to myelin in normal aging; and the identification of the unique pattern of memory loss in Alzheimer’s Disease.
Our research laboratories explore wide-ranging areas of neuroscience in both animal models (zebra fish, rodents and non-human primates) and humans alike. They focus on understanding the structure, organization, and function of cerebral systems in health and disease; the neural basis of cognitive decline in aging and age-related disorders; the neurobiology of sleep and circadian rhythms, cortical development in the normal and disordered brain; and the mechanisms of neuronal plasticity that underlie cognition.
Within these laboratories our PhD and Masters students conduct research using state-of-art methodologies, and through the Department’s unique Vesalius Program, under the guidance of our record award-winning faculty, are trained to become the next generation of highly effective and innovative educators in the biomedical sciences.
For more information visit the Anatomy & Neurobiology website.
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Neuroimaging markers for studying Gulf-War illness: single-subject level analytical method based on machine learning
(2020-11-20)Gulf War illness (GWI) refers to the multitude of chronic health symptoms, spanning from fatigue, musculoskeletal pain, and neurological complaints to respiratory, gastrointestinal, and dermatologic symptoms experienced ... -
Klotho pathways, myelination disorders, neurodegenerative diseases, and epigenetic drugs
(Mary Ann Liebert, Inc., 2020)In this review we outline a rationale for identifying neuroprotectants aimed at inducing endogenous Klotho activity and expression, which is epigenetic action, by definition. Such an approach should promote remyelination ... -
Epigenetic treatment of dermatologic disorders
(Wiley, 2019-09)Healthy skin protects us against a multitude of insults but injured or maladapted skin can lead to infection, inflammation or worse. Fortunately, naturally occurring bioactive products, many commonly found in olive oil and ... -
Automated identification of neurons and their locations
(WILEY-BLACKWELL, 2008-06-01)Individual locations of many neuronal cell bodies (>10^4) are needed to enable statistically significant measurements of spatial organization within the brain such as nearest‐neighbour and microcolumnarity measurements. ... -
Colocalization of neurons in optical coherence microscopy and Nissl-stained histology in Brodmann’s area 32 and area 21
(Springer Science and Business Media LLC, 2019-01)Optical coherence tomography is an optical technique that uses backscattered light to highlight intrinsic structure, and when applied to brain tissue, it can resolve cortical layers and fiber bundles. Optical coherence ... -
Cognitive-Behavior Therapy (CBT) for Panic Disorder: Relationship of Anxiety and Depression Comorbidity with Treatment Outcome
(Springer US, 2009-7-24)Research evaluating the relationship of comorbidity to treatment outcome for panic disorder has produced mixed results. The current study examined the relationship of comorbid depression and anxiety to treatment outcome ... -
The Circadian System Is a Target and Modulator of Prenatal Cocaine Effects
(Public Library of Science, 2007-7-11)BACKGROUND. Prenatal exposure to cocaine can be deleterious to embryonic brain development, but the results in humans remain controversial, the mechanisms involved are not well understood and effective therapies are yet ... -
Parallel Driving and Modulatory Pathways Link the Prefrontal Cortex and Thalamus
(Public Library of Science, 2007-9-5)Pathways linking the thalamus and cortex mediate our daily shifts from states of attention to quiet rest, or sleep, yet little is known about their architecture in high-order neural systems associated with cognition, emotion ... -
Effects of tamoxifen on vaginal blood flow and epithelial morphology in the rat
(BioMed Central, 2006-9-13)BACKGROUND. Tamoxifen, a selective estrogen receptor modulator with both estrogenic and anti-estrogenic activity, is widely used as adjuvant therapy in breast cancer patients. Treatment with tamoxifen is associated with ... -
Streptozotocin-induced diabetes in the rat is associated with changes in vaginal hemodynamics, morphology and biochemical markers
(BioMed Central, 2006-5-30)BACKGROUND. Diabetes is associated with declining sexual function in women. However, the effects of diabetes on genital tissue structure, innervation and function remains poorly characterized. In control and streptozotocin-treated ...
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