Department of Orthopaedic Surgery
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Communicating Study Results to Our Patients: Which Way Is Best?
(Medknow Publications, 2008-04)Before we are able to communicate evidence and evidence results to patients we must first be familiar with the common ways by which results may be presented to our patients. We describe five approaches (relative risk, risk ... -
How good is the orthopaedic literature?
(Medknow Publications, 2008-04)Randomized trials constitute approximately 3% of the orthopaedic literature Concerns regarding quality of the orthopaedic literature stem from a widespread notion that the overall quality of the surgical literature is in ... -
Thoracolumbar Injury Classification and Severity Score: A New Paradigm for the Treatment of Thoracolumbar Spine Trauma
(Springer-Verlag, 2005-08)BACKGROUND Contemporary understanding of the biomechanics, natural history, and methods of treating thoracolumbar spine injuries continues to evolve. Current classification schemes of these injuries, however, can be either ... -
The Age of Evidence-Based Orthopaedics
(Medknow Publications, 2008-04) -
Bone Marrow Lesions from Osteoarthritis Knees Are Characterized by Sclerotic Bone that Is Less Well Mineralized
(BioMed Central, 2009-1-26)INTRODUCTION. Although the presence of bone marrow lesions (BMLs) on magnetic resonance images is strongly associated with osteoarthritis progression and pain, the underlying pathology is not well established. The aim of ... -
Internet Versus Mailed Questionnaires: A Randomized Comparison (2)
(Gunther Eysenbach, 2004-9-24)BACKGROUND Low response rates among surgeons can threaten the validity of surveys. Internet technologies may reduce the time, effort, and financial resources needed to conduct surveys. OBJECTIVE We investigated whether ... -
Cox-2: Where Are We in 2003? - The Role of Cyclooxygenase-2 in Bone Repair
(BioMed Central, 2002-10-21)Prostaglandins are important mediators of bone repair, and cyclooxygenases are required for prostaglandin production. Data from animal studies suggest that both non-specific and specific inhibitors of cyclooxygenases impair ... -
DNA-like Class R Inhibitory Oligonucleotides (INH-ODNs) Preferentially Block Autoantigen-Induced B-Cell and Dendritic Cell Activation in Vitro and Autoantibody Production in Lupus-Prone MRL-Faslpr/lpr Mice in Vivo
(BioMed Central, 2009-5-28)INTRODUCTION. B cells have many different roles in systemic lupus erythematosus (SLE), ranging from autoantigen recognition and processing to effector functions (for example, autoantibody and cytokine secretion). Recent ... -
The Orthopaedic Trauma Literature: An Evaluation of Statistically Significant Findings in Orthopaedic Trauma Randomized Trials
(BioMed Central, 2008-1-29)BACKGROUND.: Evidence-based medicine posits that health care research is founded upon clinically important differences in patient centered outcomes. Statistically significant differences between two treatments may not ...