| dc.contributor.author | Favaretto, Paola | en_US |
| dc.contributor.author | Bhutkar, Arjun | en_US |
| dc.contributor.author | Smith, Temple F. | en_US |
| dc.date.accessioned | 2012-01-12T17:46:42Z | |
| dc.date.available | 2012-01-12T17:46:42Z | |
| dc.date.issued | 2005-09-09 | |
| dc.identifier.citation | Favaretto, Paola, Arjun Bhutkar, Temple F. Smith. "Constraining ribosomal RNA conformational space" Nucleic Acids Research 33(16): 5106-5111. (2005) | |
| dc.identifier.issn | 1362-4962 | |
| dc.identifier.uri | https://hdl.handle.net/2144/3441 | |
| dc.description.abstract | Despite the potential for many possible secondary-structure conformations, the native sequence of ribosomal RNA (rRNA) is able to find the correct and universally conserved core fold. This study reports a computational analysis investigating two mechanisms that appear to constrain rRNA secondary-structure conformational space: ribosomal proteins and rRNA sequence composition. The analysis was carried out by using rRNA–ribosomal protein interaction data for the Escherichia coli 16S rRNA and free energy minimization software for secondary-structure prediction. The results indicate that selection pressures on rRNA sequence composition and ribosomal protein–rRNA interaction play a key role in constraining the rRNA secondary structure to a single stable form. | en_US |
| dc.description.sponsorship | National Science Foundation (DBI-0205512); Boston University | en_US |
| dc.language.iso | en | |
| dc.publisher | Oxford University Press | en_US |
| dc.title | Constraining Ribosomal RNA Conformational Space | en_US |
| dc.type | Article | en_US |
| dc.identifier.doi | 10.1093/nar/gki805 | |
| dc.identifier.pmid | 16155182 | |
| dc.identifier.pmcid | 1214544 | |
