Lack of Association between Angiotensin-Converting Enzyme and Dementia of the Alzheimer's Type in an Elderly Arab Population in Wadi Ara, Israel

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Date Issued
2005
Author(s)
Bowirrat, Abdalla
Cui, Jing
Waraska, Kristin
Friedland, Robert P.
Oscar-Berman, Marlene
Farrer, Lindsay A.
Korczyn, Amos
Baldwin, Clinton T.
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Permanent Link
https://hdl.handle.net/2144/2953
Citation (published version)
Bowirrat, Abdalla, Jing Cui, Kristin Waraska, Robert P. Friedland, Marlene Oscar-Berman, Lindsay A. Farrer, Amos Korczyn, Clinton T. Baldwin. "Lack of association between angiotensin-converting enzyme and dementia of the Alzheimer's type in an elderly Arab population in Wadi Ara, Israel" Neuropsychiatric Disease and Treatment 1(1): 73-76. (2005)
Abstract
The angiotensin-converting enzyme (ACE), a protease involved in blood pressure regulation, has been implicated as an important candidate gene for Alzheimer's disease (AD). This study investigated whether the ACE gene insertion–deletion (ID) polymorphism is associated with risk of developing dementia of Alzheimer's type (DAT) in an Arab–Israeli community, a unique genetic isolate where there is a high prevalence of DAT. In contrast to several other studies, we found no evidence of an association between this polymorphism and either DAT or age-related cognitive decline (ARCD).
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