CAS: Chemistry: Scholarly Papers
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URI: http://hdl.handle.net/2144/1001
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Perturbation detection through modeling of gene expression on a latent biological pathway network: a Bayesian hierarchical approach
(Taylor & Francis, 2016)Cellular response to a perturbation is the result of a dynamic system of biological variables linked in a complex network. A major challenge in drug and disease studies is identifying the key factors of a biological network ... -
Targeting the oncogene LSF with either the small molecule inhibitor FQI1 or siRNA causes mitotic delays with unaligned chromosomes, resulting in cell death or senescence
(Springer Science and Business Media LLC, 2020-06-15)BACKGROUND: The oncogene LSF (encoded by TFCP2) has been proposed as a novel therapeutic target for multiple cancers. LSF overexpression in patient tumors correlates with poor prognosis in particular for both hepatocellular ... -
The microtubule-associated histone methyltransferase SET8, facilitated by transcription factor LSF, methylates α-tubulin
(Elsevier BV, 2020-04-03)Microtubules are cytoskeletal structures critical for mitosis, cell motility, and protein and organelle transport and are a validated target for anticancer drugs. However, how tubulins are regulated and recruited to support ... -
Factor quinolinone inhibitors alter cell morphology and motility by destabilizing interphase microtubules
(Springer Science and Business Media LLC, 2021-12-07)Factor quinolinone inhibitors are promising anti-cancer compounds, initially characterized as specific inhibitors of the oncogenic transcription factor LSF (TFCP2). These compounds exert anti-proliferative activity at least ... -
Factor quinolinone inhibitors disrupt spindles and multiple LSF (TFCP2)-protein interactions in mitosis, including with microtubule-associated proteins
(Public Library of Science (PLoS), 2022)Factor quinolinone inhibitors (FQIs), a first-in-class set of small molecule inhibitors targeted to the transcription factor LSF (TFCP2), exhibit promising cancer chemotherapeutic properties. FQI1, the initial lead compound ... -
OvoAMtht from Methyloversatilis thermotolerans ovothiol biosynthesis is a bifunction enzyme: thiol oxygenase and sulfoxide synthase activities
(Royal Society of Chemistry (RSC), 2022-03-24)Mononuclear non-heme iron enzymes are a large class of enzymes catalyzing a wide-range of reactions. In this work, we report that a non-heme iron enzyme in Methyloversatilis thermotolerans, OvoAMtht, has two different ... -
Dissecting the mechanism of the nonheme iron endoperoxidase FtmOx1 using substrate analogues
(American Chemical Society (ACS), 2022-07-25)FtmOx1 is a nonheme iron (NHFe) endoperoxidase, catalyzing three disparate reactions, endoperoxidation, alcohol dehydrogenation, and dealkylation, under in vitro conditions; the diversity complicates its mechanistic studies. ... -
Formation and evolution of metallocene single-molecule circuits with direct gold-π links
(American Chemical Society (ACS), 2022-04-13)Single-molecule circuits with group 8 metallocenes are formed without additional linker groups in scanning tunneling microscope-based break junction (STMBJ) measurements at cryogenic and room-temperature conditions with ... -
Atomically precise binding conformations of adenine and its variants on gold using single molecule conductance signatures
(AIP Publishing, 2022-12-21)We demonstrate single molecule conductance as a sensitive and atomically precise probe of binding configurations of adenine and its biologically relevant variants on gold. By combining experimental measurements and density ... -
Effect of lattice mismatch on film morphology of the quasi-one dimensional conductor K0.3MoO3
(Royal Society of Chemistry (RSC), 2022-02-03)High quality epitaxial thin films of the quasi-one dimensional conductor K0.3MoO3 have been successfully grown on SrTiO3(100), SrTiO3(110), and SrTiO3(510) substrates via pulsed laser deposition. Scanning electron microscopy ...
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